Corneal Cross-Linking

iromed cfx-linker
CFX Linker logo

Corneal Cross-linking System

CF X-LINKER is a versatile corneal cross-linking system offering a wide variety of treatments, including Iromed’s proprietary customized Custom Fast EPI-ON Protocol.

  • Open system: No need for additional costs or items (e.g. activation key)
  • Wide treatment range: Dresden EPI-OFF, Standard EPI-ON, Accelerated, User presets, Keratitis, Iontophoresis, CUSTOM FAST CXL (only with RIBOCROSS te® and RIBOFAST)
  • Always connected: the system can be connected via WiFi and LAN, and has an integrated treatment report archive that allows to store, print, or save the reports on an external USB

  • Customized
    • Topo-pachimetric guided treatment
    • Customized procedure parameters
    • Noninvasive EPI-ON technique
    • Endothelial safeguard with no additional soaking needed
    • Suitable for thin corneas
  • Innovative
    • Vitamin E TPGS – enhanced riboflavin for improved corneal penetration with safe and effective results
  • Peer-reviewed
    • Multiple peer-reviewed publications
    • 7-year follow-up published on Cornea

  • 10” touchscreen display
  • Integrated camera
  • UV power: 1-30 mW/cm2 – continuous and pulsed
  • 3-12 mm adjustable diameter
  • Lan and WiFi ready
  • Treatment report archive
  • Remote assistance
  • Locking wheels and multi-point arm locking system
  • Class IIA CE Medical Device

  • “Corneal collagen cross-linking in patients with keratoconus from the Dresden protocol to customized solutions: theoretical basis” Int J Ophthalmol, Vol. 17, No. 5, May 18, 2024.
  • “Topo-pachimetric accelerated EPI-ON cross-linking compared to the Dresden protocol using riboflavin with Vitamin E TPGS: results of a 2-year randomized study” J. Clin. Med. 2021, 10, 3799.
  • “Compaction of very thin corneas from ultraviolet A riboflavin-vitamin E transepithelial cross-linking” Experimental Eye Research 205 (2021) 108484.
  • “Topography and Pachymetry Guided, Rapid Epi-on Corneal Cross-Linking for Keratoconus: 7-year Study Results” Cornea 2020;39:56–62.
  • “Corneal Cross-Linking – The Science Beyond the Myths and Misconceptions” Cornea. 2019 Jun;38(6):780-790.
  • “Customized Corneal Cross-linking – A Mathematical Model” Cornea 2017;36:600–604.
  • “Corneal Cross-Linking: Evaluating the Potential for a Lower Power, Shorter Duration Treatment” Cornea 2016;35:659–662.
  • “Transepithelial Corneal Cross-Linking With Vitamin E-Enhanced Riboflavin Solution and Abbreviated, Low-Dose UV-A: 24-Month Clinical Outcomes” Cornea 2016;35:145–150.
  • “Enhancement of corneal permeation of riboflavin-5’-phosphate through vitamin E TPGS: A promising approach in corneal trans-epithelial cross linking treatment”. Inter J Pharm 440 (2013) 148– 153.
riboflavine iromed

Vitamin E TPGS-enhanced Riboflavin solutions.

RIBOCROSS® te and RIBOFAST are Iromed’s CXL riboflavin solutions. Their innovative formulations with Vitamin E TPGS provide high corneal penetration and improved performances. They can be used with different UV devices and CXL procedures.

  • Patented: innovative formulations with Vitamin E TPGS as penetration enhancer
  • High performances: improved and faster corneal penetration thanks to Vitamin E TPGS
  • Versatile: can be used with any UV lamp
  • Exclusive: the only riboflavin solutions for Custom Fast CXL protocol (only with the CF X-LINKER System)

RIBOCROSS te: patented formulation of Riboflavin 0.1% with penetration enhancer (Vitamin E TPGS) & 10% Dextran. RIBOFAST: Dextran free, patented formulation of Riboflavin 0.1% with penetration enhancer (Vitamin E TPGS).

  • 5 ml single-use pre-filled syringe
  • Class IIA CE Medical Device
  • Shelf life: 2 years

  • “Corneal collagen cross-linking in patients with keratoconus from the Dresden protocol to customized solutions: theoretical basis” Int J Ophthalmol, Vol. 17, No. 5, May 18, 2024.
  • “Topo-pachimetric accelerated EPI-ON cross-linking compared to the Dresden protocol using riboflavin with Vitamin E TPGS: results of a 2-year randomized study” J. Clin. Med. 2021, 10, 3799.
  • “Compaction of very thin corneas from ultraviolet A riboflavin-vitamin E transepithelial cross-linking” Experimental Eye Research 205 (2021) 108484.
  • “Topography and Pachymetry Guided, Rapid Epi-on Corneal Cross-Linking for Keratoconus: 7-year Study Results” Cornea 2020;39:56–62.
  • “Corneal Cross-Linking – The Science Beyond the Myths and Misconceptions” Cornea. 2019 Jun;38(6):780-790.
  • “Customized Corneal Cross-linking – A Mathematical Model” Cornea 2017;36:600–604.
  • “Corneal Cross-Linking: Evaluating the Potential for a Lower Power, Shorter Duration Treatment” Cornea 2016;35:659–662.
  • “Transepithelial Corneal Cross-Linking With Vitamin E-Enhanced Riboflavin Solution and Abbreviated, Low-Dose UV-A: 24-Month Clinical Outcomes” Cornea 2016;35:145–150.
  • “Enhancement of corneal permeation of riboflavin-5’-phosphate through vitamin E TPGS: A promising approach in corneal trans-epithelial cross linking treatment”. Inter J Pharm 440 (2013) 148– 153.

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