RIBOFLAVIN - RIBOCROSS & RIBOFAST


IROMED GROUP DEVELOPED ITS PATENTED RIBOFLAVIN SOLUTIONS, CE MARKED AND COMPATIBLE WITH EVERY CXL PROTOCOL AND UV DEVICE ON THE MARKET

RIBOCROSS TE and RIBOFAST ARE THE ONLY SOLUTIONS IN THE WORLD TO USE VITAMIN E TPGS AS PENETRATION ENHANCER. SAFE AND EFFECTIVE RESULTS IN BOTH EPI-OFF AND EPI-ON.

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UNIQUENESS AND INNOVATION

Iromed Group’s riboflavin solutions have unique, innovative and patented formulations: thanks to Vitamin E TPGS, in synergy with riboflavin, is it possible to get safe and effective results in both EPI-OFF and EPI-ON, certified by international publications, with a 7-year follow up.

 

CUSTOM FAST CXL

RIBOCROSS ® te and RIBOFAST are the only riboflavin solutions that can be used in Custom Fast CXL (cfCXL), exclusive customized low power EPI-ON treatment, in combination with CF X-LINKER ® system.

The proprietary software use a mathematical model to calculate treatment parameters, based on patients’ topographic and pachymetric data: this leads to a custom made treatment, tailored on every patients’ needs, that allows for a safe and effective procedure.

Custom Fast CXL is supported by clinical studies and publications on international papers, with a clinical 7-year follow up, unique among EPI-ON procedures. Custom Fast CXL can be performed only with CF X-LINKER ® system and RIBOCROSS ® te/RIBOFAST solutions.


RIBOCROSS te


Ophthalmic solution for Corneal Cross-linking

RIBOCROSS ® te is a patented ophthalmic solution, fit for every CXL protocol. Thanks to Vitamin E TPGS as an enhancer, it allows for an effective penetration in the whole corneal stroma, even in EPI-ON, for safe and effective results.

 

Features:

  • Ophthalmic solution with 10% Dextran;
  • International patent;
  • Vitamin E TPGS: corneal penetration enhancer;
  • High effectiveness in both EPI-ON and EPI-OFF;
  • Can be used with every protocol and UV device on the market;
  • Can be used in CUSTOM FAST CXL (cfCXL).

SERVImed Industrial è un’azienda di Ricerca, Sviluppo, Produzione e distribuzione di Dispositivi Medici. La missione è affiancare il mondo medicale con prodotti, servizi e soluzioni all’avanguardia

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RIBOFAST


titolo

Dextran free ophthalmic solution for Corneal Cross-linking

RIBOFAST is a patented dextran free ophthalmic solution, fit for every CXL protocol. Thanks to Vitamin E TPGS as an enhancer, it allows for an effective penetration in the whole corneal stroma, even in EPI-ON, for safe and effective results.

 

Features:

  • Dextran free ophthalmic solution;
  • International patent;
  • Vitamin E TPGS: corneal penetration enhancer;
  • High effectiveness in both EPI-ON and EPI-OFF;
  • Can be used with every protocol and UV device on the market;
  • Can be used in CUSTOM FAST CXL (cfCXL).

SERVImed Industrial è un’azienda di Ricerca, Sviluppo, Produzione e distribuzione di Dispositivi Medici. La missione è affiancare il mondo medicale con prodotti, servizi e soluzioni all’avanguardia

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BIBLIOGRAPHY

  1. Ciro Caruso, Salvatore Troisi, Antonio Del Prete, Luigi Pacente, Gaetano Barbaro, Carmine Ostacolo, Salvatore Del Prete “Evaluation of the penetration through human cornea of riboflavin 0.1% in solution with other molecules after trans-epithelial application”. 1st EuCornea Congress, June 17-19 2010, Venice, Italy [PDF]

  2. Robert L. Epstein, Salvatore Del Prete, Ciro Caruso, Salvatore Troisi, Carmine Ostacolo, Luigi Pacente, Antonio Del Prete, Gaetano Barbaro “Thickness and ultra-structural changes in keratoconus-affected human corneas after transepithelial cross-linking” American Academy of Ophthalmology Annual Meeting, October 2010, Chicago (P0073). [PDF]

  3. Robert L. Epstein, Ciro Caruso, Carmine Ostacolo, Salvatore Troisi, Luigi Pacente, Gaetano Barbaro, Antonio Del Prete, Antonia Sacchi: “A new riboflavin solution for trans-epithelial cross-linking: a study of corneal pharmacokinetic” American Academy of Ophthalmology Annual Meeting, October 2010, Chicago (P0073). [PDF]

  4. Salvatore Del Prete, Ciro Caruso, Luigi Pacente, Salvatore Troisi, Antonio Del Prete, Gaetano Barbaro “Effects of UV-A rays on the corneal epithelial surface after topical application of riboflavin solutions: an electron microscope study”. American Academy of Ophthalmology Annual Meeting, October 2010, Chicago (P0073) [PDF]

  5. Gaetano Barbaro, Ciro Caruso, Salvatore Troisi, Antonio Del Prete, Luigi Pacente “A Mathematical Model of Corneal UV-A Absorption After Soaking With a Riboflavin Solution During Trans-epithelial Cross-linking”. 1st Refractive Online and SICSSO Joint International Congress, July 7-9, 2011, Grosseto, Italy (Best paper, podium presentation) [PDF]

  6. Ciro Caruso, Salvatore Troisi, Gaetano Barbaro, Carmine Ostacolo, Antonio Del Prete, Luigi Pacente “UV-A rays absorption in human corneas before and after trans-epithelial riboflavin application: an experimental study”. 2nd Refractive Online and SICSSO Joint International Congress, June 28-30, 2012, Rome, Italy (Podium presentation) [PDF]

  7. Ciro Caruso, Salvatore Troisi, Antonio Del Prete, Luigi Pacente, Gaetano Barbaro “Trans-epithelial cross-linking with riboflavin solution: one-year clinical results”. 1st Refractive Online and SICSSO Joint International Congress, July 7-9, 2011, Grosseto, Italy (Podium presentation) [PDF]

  8. Ciro Caruso, Luigi Pacente, Robert L. Epstein, Salvatore Troisi, Gaetano Barbaro, Antonio Del Prete: “Trans-epithelial cross-linking with riboflavin solution: two-year clinical results” 2nd joint International Congress Refractive Online & SICSSO, Rome 2012 (podium presentation). [PDF]

  9. Carmine Ostacolo, Ciro Caruso, Diana Tronino, Salvatore Troisi, Sonia Laneri, Luigi Pacente, Antonio Del Prete, Antonia Sacchi “Increasing of corneal permeation of riboflavin-5′-phosphate through enhancers: A promising approach in corneal trans-epithelial cross-linking treatment” Inter J Pharm 440 (2013) 148– 153. [PDF]

  10. Ciro Caruso, Carmine Ostacolo, Robert L. Epstein, Gaetano Barbaro, Salvatore Troisi, Decio Capobianco: “Transepithelial Corneal Cross-Linking With Vitamin E-Enhanced Riboflavin Solution and Abbreviated, Low-Dose UV-A: 24-Month Clinical Outcomes” Cornea 2016;35:145–150. [PDF]

  11. Ciro Caruso, Gaetano Barbaro, Robert L. Epstein, Diana Tronino, Carmine Ostacolo, Antonia Sacchi, Luigi Pacente, Antonio Del Prete, Marina Sala, Salvatore Troisi: “Corneal Cross-Linking: Evaluating the Potential for a Lower Power, Shorter Duration Treatment” Cornea 2016;35:659–662. [PDF]

  12. Ciro Caruso, Robert L. Epstein, Carmine Ostacolo, Luigi Pacente, Salvatore Troisi, Gaetano Barbaro. “Customized Corneal Cross-linking – A Mathematical Model” Cornea 2017; 36:600–604. [PDF]

  13. Roy S. Rubinfeld, Ciro Caruso, Carmine Ostacolo “Corneal Cross-Linking - The Science Beyond the Myths and Misconceptions” Cornea 2019 Jun;38(6):780-790. [Pdf]

  14. Ciro Caruso, Robert L. Epstein, Pasquale Troiano, Carmine Ostacolo, Gaetano Barbaro, Luigi Pacente, Silvia Bartollino, Ciro Costagliola “Topography and Pachymetry Guided, Rapid Epi-on Corneal Cross-Linking for Keratoconus: 7-year Study Results” Cornea 2020;39:56–62. [PDF]
  15. Ciro Caruso, Ciro Costagliola, Salvatore Troisi, Robert L. Epstein “Compaction of very thin corneas from ultraviolet A riboflavin-vitamin E transepithelial cross-linking” Experimental Eye Research 205 (2021) 108484. [PDF]